昭和28(1953)年10月1日、「大和高田市民病院」の名前で、厚生省(今の厚生労働省)指定のモデル病院として大和高田市大字大中281番地にたてられました。当時、一般病床(入院ベッド)数は85床。診察は内科、外科、小児科、産婦人科、放射線科の5科がありました。
　昭和45(1970)年12月、「大和高田市立病院」と名前があらためられて、いまの礒野北町に新しくたてられました。平成23(2011)年11月には一般病床が320床にまでふえ、今では24科(平成28年)の診察ができます。人と人とのふれあいをよろこびとし、安心と信頼にささえられた活力のある病院をめざして、人びとを助けています。
 
On October 1, 1953, the present-day Yamato Takada City Hospital, which was designated as a model hospital by the Ministry of Health and Welfare (currently, the Ministry of Health, Labour and Welfare), was built at Oaza Onaka 281, Yamato Takada City and named “Yamato Takada Civilian Hospital.” At that time, the hospital had 85 general hospital beds (for admissions), and five departments: Internal Medicine, Surgery, Pediatrics, Obstetrics/Gynecology, and Radiology．
In December 1970, the hospital was renamed the “Yamato Takada City Hospital,” and rebuilt in the area currently called Isonokita Cho. The number of general beds increased to 320 beds by November 2011, and the hospital now offers a wide variety of services through 24 departments (as of 2016). The hospital has been helping people with the aim of becoming a vibrant hospital that values person-to-person interaction and is supported by trust and reliability．